Ontology highlight
ABSTRACT:
SUBMITTER: Vanneste M
PROVIDER: S-EPMC6361972 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Vanneste Marion M Huang Qin Q Li Mengshi M Moose Devon D Zhao Lei L Stamnes Mark A MA Schultz Michael M Wu Meng M Henry Michael D MD
Scientific reports 20190204 1
Epithelial-to-mesenchymal transition (EMT) is implicated in cancer metastasis and drug resistance. Specifically targeting cancer cells in an EMT-like state may have therapeutic value. In this study, we developed a cell imaging-based high-content screening protocol to identify EMT-selective cytotoxic compounds. Among the 2,640 compounds tested, salinomycin and monensin, both monovalent cation ionophores, displayed a potent and selective cytotoxic effect against EMT-like cells. The mechanism of ac ...[more]