Targeting cardiomyocyte Ca2+ homeostasis in heart failure.
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ABSTRACT:
SUBMITTER: Roe AT
PROVIDER: S-EPMC4475738 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Targeting cardiomyocyte Ca2+ homeostasis in heart failure.
Roe Asmund T AT Frisk Michael M Louch William E WE
Current pharmaceutical design 20150101 4
Improved treatments for heart failure patients will require the development of novel therapeutic strategies that target basal disease mechanisms. Disrupted cardiomyocyte Ca(2+) homeostasis is recognized as a major contributor to the heart failure phenotype, as it plays a key role in systolic and diastolic dysfunction, arrhythmogenesis, and hypertrophy and apoptosis signaling. In this review, we outline existing knowledge of the involvement of Ca(2+) homeostasis in these deficits, and identify fo ...[more]
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