Ontology highlight
ABSTRACT:
SUBMITTER: Saliba AN
PROVIDER: S-EPMC4476479 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Journal of blood medicine 20150617
Transfusional iron overload is a major target in the care of patients with transfusion-dependent thalassemia (TDT) and other refractory anemias. Iron accumulates in the liver, heart, and endocrine organs leading to a wide array of complications. In this review, we summarize the characteristics of the approved iron chelators, deferoxamine, deferiprone, and deferasirox, and the evidence behind the use of each, as monotherapy or as part of combination therapy. We also review the different guideline ...[more]