Unknown

Dataset Information

0

GDM Women's Pre-Pregnancy Overweight/Obesity and Gestational Weight Gain on Offspring Overweight Status.


ABSTRACT:

Objectives

To examine the association of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with anthropometry in the offspring of mothers with gestational diabetes mellitus (GDM).

Methods

We performed a retrospective cohort study in 1263 GDM mother-child pairs. General linear models and Logistic regression models were used to assess the single and joint associations of maternal pre-pregnancy BMI (normal weight, overweight, and obesity) and GWG (inadequate, adequate and excessive GWG) with anthropometry and overweight status in the offspring from birth to 1-5 years old.

Results

Maternal pre-pregnancy BMI and GWG were positively associated with birth weight for gestational age Z score and birth weight for length for gestational age Z score at birth, and weight for age Z score, length/height for age Z score, and weight for length/height Z score at of 1-5 years old offspring. Maternal pre-pregnancy overweight, obesity, and excessive GWG were associated with increased risks of large for gestational age [ORs 95% CIs = 1.87 (1.37-2.55), 2.98 (1.89-4.69), and 2.93 (2.07-4.13), respectively] and macrosomia [ORs 95% CIs = 2.06 (1.50-2.84), 2.89 (1.78-4.70), and 2.84 (1.98-4.06), respectively] at birth and childhood overweight at 1-5 years old [ORs 95% CIs = 1.26 (0.92-1.73), 1.96 (1.24-3.09), and 1.59 (1.15-2.21), respectively].

Conclusions

Offspring born to GDM mothers with pre-pregnancy overweight/obesity or excessive GWG were associated with increased risks of large for gestational age and macrosomia at birth, and childhood overweight at 1-5 years old, compared with those born to GDM mothers with pre-pregnancy normal weight and adequate GWG.

SUBMITTER: Leng J 

PROVIDER: S-EPMC4476720 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

altmetric image

Publications

GDM Women's Pre-Pregnancy Overweight/Obesity and Gestational Weight Gain on Offspring Overweight Status.

Leng Junhong J   Li Weiqin W   Zhang Shuang S   Liu Huikun H   Wang Leishen L   Liu Gongshu G   Li Nan N   Redman Leanne M LM   Baccarelli Andrea A AA   Hou Lifang L   Hu Gang G  

PloS one 20150622 6


<h4>Objectives</h4>To examine the association of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with anthropometry in the offspring of mothers with gestational diabetes mellitus (GDM).<h4>Methods</h4>We performed a retrospective cohort study in 1263 GDM mother-child pairs. General linear models and Logistic regression models were used to assess the single and joint associations of maternal pre-pregnancy BMI (normal weight, overweight, and obesity) and GWG (inadequ  ...[more]

Similar Datasets

| S-EPMC10084734 | biostudies-literature
| S-EPMC6518700 | biostudies-literature
| S-EPMC4865436 | biostudies-literature
| S-EPMC7355601 | biostudies-literature
| S-EPMC4827014 | biostudies-other
| S-EPMC6070475 | biostudies-other
| S-EPMC6385743 | biostudies-literature
| S-EPMC9329274 | biostudies-literature
| S-EPMC4379119 | biostudies-literature
| S-EPMC6354939 | biostudies-literature