Ontology highlight
ABSTRACT: From the clinical editor
Excessive exposure to the sun is known to increase the risk of skin cancer due to DNA damage. In this work, the authors tested the use of silver nanoparticles as protective agents against ultraviolet radiation. The positive results may open a door for the use of silver nanoparticle as novel agents in the future.
SUBMITTER: Arora S
PROVIDER: S-EPMC4476928 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Arora Sumit S Tyagi Nikhil N Bhardwaj Arun A Rusu Lilia L Palanki Rohan R Vig Komal K Singh Shree R SR Singh Ajay P AP Palanki Srinivas S Miller Michael E ME Carter James E JE Singh Seema S
Nanomedicine : nanotechnology, biology, and medicine 20150321 5
Ultraviolet (UV)-B radiation from the sun is an established etiological cause of skin cancer, which afflicts more than a million lives each year in the United States alone. Here, we tested the chemopreventive efficacy of silver-nanoparticles (AgNPs) against UVB-irradiation-induced DNA damage and apoptosis in human immortalized keratinocytes (HaCaT). AgNPs were synthesized by reduction-chemistry and characterized for their physicochemical properties. AgNPs were well tolerated by HaCaT cells and t ...[more]