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Silver Nanoparticles Protect Skin from Ultraviolet B-Induced Damage in Mice.

ABSTRACT: Ultraviolet (UV) radiation from sunlight has various adverse effects; thus, UV blockage is recommended for preventing sunburn. Common sunscreen ingredients, such as nanosized titanium dioxide and zinc oxide, offer effective protection and enhance cosmetic appearance; however, health concerns have been raised regarding their photocatalytic activity, which generates reactive oxygen species under UV illumination. Silver nanoparticles (AgNPs) are known as safe materials for use in a wide spectrum of biomedical applications. In vitro studies have revealed that AgNPs may have a protective effect against UV irradiation, but the effects in animal studies remain unclear. The present study demonstrated that AgNPs effectively protect against UVB-induced skin damage both in cell cultures and mouse models. These results suggested that AgNPs are feasible and safe as sunscreen ingredients for protection against UVB-induced skin damage.

SUBMITTER: Ho YY

PROVIDER: S-EPMC7582269 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Silver Nanoparticles Protect Skin from Ultraviolet B-Induced Damage in Mice.

Ho Yu-Yi YY Sun Der-Shan DS Chang Hsin-Hou HH

International journal of molecular sciences 20200925 19

Ultraviolet (UV) radiation from sunlight has various adverse effects; thus, UV blockage is recommended for preventing sunburn. Common sunscreen ingredients, such as nanosized titanium dioxide and zinc oxide, offer effective protection and enhance cosmetic appearance; however, health concerns have been raised regarding their photocatalytic activity, which generates reactive oxygen species under UV illumination. Silver nanoparticles (AgNPs) are known as safe materials for use in a wide spectrum of ...[more]

PMID: 32992921

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