Ontology highlight
ABSTRACT:
SUBMITTER: Parrish JK
PROVIDER: S-EPMC4477825 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Parrish J K JK Sechler M M Winn R A RA Jedlicka P P
Oncogene 20131223 2
Ewing Sarcoma is a biologically aggressive bone and soft tissue malignancy affecting children and young adults. Ewing Sarcoma pathogenesis is driven by EWS/Ets fusion oncoproteins, of which EWS/Fli1 is the most common. We have previously shown that microRNAs (miRs) regulated by EWS/Fli1 contribute to the pro-oncogenic program in Ewing Sarcoma. Here we show that miR-22, an EWS/Fli1-repressed miR, is inhibitory to Ewing Sarcoma clonogenic and anchorage-independent cell growth, even at modest overe ...[more]