Identifying Novel Clinical Surrogates to Assess Human Bone Fracture Toughness.
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ABSTRACT:
SUBMITTER: Granke M
PROVIDER: S-EPMC4478129 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Identifying Novel Clinical Surrogates to Assess Human Bone Fracture Toughness.
Granke Mathilde M Makowski Alexander J AJ Uppuganti Sasidhar S Does Mark D MD Nyman Jeffry S JS
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20150608 7
Fracture risk does not solely depend on strength but also on fracture toughness; ie, the ability of bone material to resist crack initiation and propagation. Because resistance to crack growth largely depends on bone properties at the tissue level, including collagen characteristics, current X-ray based assessment tools may not be suitable to identify age-related, disease-related, or treatment-related changes in fracture toughness. To identify useful clinical surrogates that could improve the as ...[more]
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