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Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures.

ABSTRACT: Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding.

SUBMITTER: Moyer TJ 

PROVIDER: S-EPMC4478239 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures.

Moyer Tyson J TJ   Kassam Hussein A HA   Bahnson Edward S M ES   Morgan Courtney E CE   Tantakitti Faifan F   Chew Teng L TL   Kibbe Melina R MR   Stupp Samuel I SI  

Small (Weinheim an der Bergstrasse, Germany) 20150203 23

Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding. ...[more]

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