Ontology highlight
ABSTRACT:
SUBMITTER: Salazar DA
PROVIDER: S-EPMC4478251 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Salazar Dominique A DA Butler Victoria J VJ Argouarch Andrea R AR Hsu Tsung-Yuan TY Mason Amanda A Nakamura Ayumi A McCurdy Helen H Cox David D Ng Rachel R Pan Gloria G Seeley William W WW Miller Bruce L BL Kao Aimee W AW
The Journal of neuroscience : the official journal of the Society for Neuroscience 20150601 25
Mutations in the human progranulin gene resulting in protein haploinsufficiency cause frontotemporal lobar degeneration with TDP-43 inclusions. Although progress has been made in understanding the normal functions of progranulin and TDP-43, the molecular interactions between these proteins remain unclear. Progranulin is proteolytically processed into granulins, but the role of granulins in the pathogenesis of neurodegenerative disease is unknown. We used a Caenorhabditis elegans model of neurona ...[more]