Endocytosis regulates TDP-43 toxicity and turnover.
Ontology highlight
ABSTRACT:
SUBMITTER: Liu G
PROVIDER: S-EPMC5727062 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Endocytosis regulates TDP-43 toxicity and turnover.
Liu Guangbo G Coyne Alyssa N AN Pei Fen F Vaughan Spencer S Chaung Matthew M Zarnescu Daniela C DC Buchan J Ross JR
Nature communications 20171212 1
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease. ALS-affected motor neurons exhibit aberrant localization of a nuclear RNA binding protein, TDP-43, into cytoplasmic aggregates, which contributes to pathology via unclear mechanisms. Here, we demonstrate that TDP-43 turnover and toxicity depend in part upon the endocytosis pathway. TDP-43 inhibits endocytosis, and co-localizes strongly with endocytic proteins, including in ALS patient tissue. Impairing endocytosis ...[more]
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