Genetic Consequences of Antiviral Therapy on HIV-1.
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ABSTRACT:
SUBMITTER: Arenas M
PROVIDER: S-EPMC4478298 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Genetic Consequences of Antiviral Therapy on HIV-1.
Computational and mathematical methods in medicine 20150610
A variety of enzyme inhibitors have been developed in combating HIV-1, however the fast evolutionary rate of this virus commonly leads to the emergence of resistance mutations that finally allows the mutant virus to survive. This review explores the main genetic consequences of HIV-1 molecular evolution during antiviral therapies, including the viral genetic diversity and molecular adaptation. The role of recombination in the generation of drug resistance is also analyzed. Besides the investigat ...[more]
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