Ontology highlight
ABSTRACT:
SUBMITTER: Swamy M
PROVIDER: S-EPMC4479038 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Swamy Mahima M Abeler-Dörner Lucie L Chettle James J Mahlakõiv Tanel T Goubau Delphine D Chakravarty Probir P Ramsay George G Reis e Sousa Caetano C Staeheli Peter P Blacklaws Barbara A BA Heeney Jonathan L JL Hayday Adrian C AC
Nature communications 20150519
Unrelenting environmental challenges to the gut epithelium place particular demands on the local immune system. In this context, intestinal intraepithelial lymphocytes (IEL) compose a large, highly conserved T cell compartment, hypothesized to provide a first line of defence via cytolysis of dysregulated intestinal epithelial cells (IEC) and cytokine-mediated re-growth of healthy IEC. Here we show that one of the most conspicuous impacts of activated IEL on IEC is the functional upregulation of ...[more]