High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET imaging.
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ABSTRACT:
SUBMITTER: Javed MR
PROVIDER: S-EPMC4479166 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
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High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET imaging.
Javed Muhammad Rashed MR Chen Supin S Lei Jack J Collins Jeffrey J Sergeev Maxim M Kim Hee-Kwon HK Kim Chang-Jin CJ van Dam R Michael RM Keng Pei Yuin PY
Chemical communications (Cambridge, England) 20140201 10
[(18)F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol(-1) (20 Ci μmol(-1)) (n = 4). Specific activity was ~2-fold higher than [(18)F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip. ...[more]
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