Ontology highlight
ABSTRACT:
SUBMITTER: Cappi C
PROVIDER: S-EPMC4479271 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Cappi Carolina C Muniz Renan Kawano RK Sampaio Aline Santos AS Cordeiro Quirino Q Brentani Helena H Palácios Selma A SA Marques Andrea H AH Vallada Homero H Miguel Eurípedes Constantino EC Guilherme Luiza L Hounie Ana Gabriela AG
Arquivos de neuro-psiquiatria 20120201 2
Obsessive-compulsive disorder (OCD) is a prevalent psychiatric disorder of unknown etiology. However, there is some evidence that the immune system may play an important role in its pathogenesis. In the present study, two polymorphisms (rs1800795 and rs361525) in the promoter region of the cytokine tumor necrosis factor-alpha (TNFA) gene were genotyped in 183 OCD patients and in 249 healthy controls. The statistical tests were performed using the PLINK(®) software. We found that the A allele of ...[more]