Ontology highlight
ABSTRACT:
SUBMITTER: Sampaio AS
PROVIDER: S-EPMC6493828 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Sampaio Aline S AS Fagerness Jesen J Crane Jacquelyn J Leboyer Marion M Delorme Richard R Pauls David L DL Stewart S Evelyn SE
CNS neuroscience & therapeutics 20100329 3
Several studies support a genetic influence on obsessive-compulsive disorder (OCD) etiology. The role of glutamate as an important neurotransmitter affecting OCD pathophysiology has been supported by neuroimaging, animal model, medication, and initial candidate gene studies. Genes involved in glutamatergic pathways, such as the glutamate receptor, ionotropic, kainate 2 (GRIK2), have been associated with OCD in previous studies. This study examines GRIK2 as a candidate gene for OCD susceptibility ...[more]