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Highly functionalized donor-acceptor cyclopropanes applied toward the synthesis of the Melodinus alkaloids.

ABSTRACT: A series of highly substituted vinylcyclopropanes were prepared and examined as reaction partners in a palladium-catalyzed (3 + 2) cycloaddition with nitrostyrenes. Described herein are our efforts to synthesize an elusive 1,1-divinylcyclopropane by several distinct approaches, and to apply surrogates of this fragment toward the synthesis of the Melodinus alkaloids.

SUBMITTER: Goldberg AF

PROVIDER: S-EPMC4479304 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Highly functionalized donor-acceptor cyclopropanes applied toward the synthesis of the <i>Melodinus</i> alkaloids.

Goldberg Alexander F G AF Craig Robert A RA O'Connor Nicholas R NR Stoltz Brian M BM

Tetrahedron letters 20150601 23

A series of highly substituted vinylcyclopropanes were prepared and examined as reaction partners in a palladium-catalyzed (3 + 2) cycloaddition with nitrostyrenes. Described herein are our efforts to synthesize an elusive 1,1-divinylcyclopropane by several distinct approaches, and to apply surrogates of this fragment toward the synthesis of the <i>Melodinus</i> alkaloids. ...[more]

PMID: 26120207

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