Ontology highlight
ABSTRACT:
SUBMITTER: Rao E
PROVIDER: S-EPMC4480727 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Rao Enyu E Zhang Yuwen Y Zhu Ganqian G Hao Jiaqing J Persson Xuan-Mai T XM Egilmez Nejat K NK Suttles Jill J Li Bing B
Oncotarget 20150401 10
A number of studies have linked AMPK, a major metabolic sensor coordinating of multiple cellular functions, to tumor development and progression. However, the exact role of AMPK in tumor development is still controversial. Here we report that activation of AMPK promotes survival and anti-tumor function of T cells, in particular CD8+ T cells, resulting in superior tumor suppression in vivo. While AMPK expression is dispensable for T cell development, genetic deletion of AMPK promotes T cell death ...[more]