Ontology highlight
ABSTRACT:
SUBMITTER: Saito Y
PROVIDER: S-EPMC4855203 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Saito Yoshimasa Y Nakaoka Toshiaki T Sakai Kasumi K Muramatsu Toshihide T Toshimitsu Kohta K Kimura Masaki M Kanai Takanori T Sato Toshiro T Saito Hidetsugu H
Scientific reports 20160504
Recent studies have proposed that the major anti-tumor effect of DNA methylation inhibitors is induction of interferon-responsive genes via dsRNAs-containing endogenous retroviruses. Recently, a 3D culture system for stem cells known as organoid culture has been developed. Lgr5-positive stem cells form organoids that closely recapitulate the properties of original tissues. To investigate the effect of DNA demethylation on tumor organoids, we have established organoids from intestinal tumors of A ...[more]