Ontology highlight
ABSTRACT:
SUBMITTER: Gusev FE
PROVIDER: S-EPMC6797775 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Gusev Fedor E FE Reshetov Denis A DA Mitchell Amanda C AC Andreeva Tatiana V TV Dincer Aslihan A Grigorenko Anastasia P AP Fedonin Gennady G Halene Tobias T Aliseychik Maria M Filippova Elena E Weng Zhiping Z Akbarian Schahram S Rogaev Evgeny I EI
Translational psychiatry 20191017 1
Both heritability and environment contribute to risk for schizophrenia. However, the molecular mechanisms of interactions between genetic and non-genetic factors remain unclear. Epigenetic regulation of neuronal genome may be a presumable mechanism in pathogenesis of schizophrenia. Here, we performed analysis of open chromatin landscape of gene promoters in prefrontal cortical (PFC) neurons from schizophrenic patients. We cataloged cell-type-based epigenetic signals of transcriptional start site ...[more]