Ontology highlight
ABSTRACT:
SUBMITTER: Richards KA
PROVIDER: S-EPMC4481611 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Richards Katherine A KA Nayak Jennifer J Chaves Francisco A FA DiPiazza Anthony A Knowlden Zackery A G ZA Alam Shabnam S Treanor John J JJ Sant Andrea J AJ
The Journal of infectious diseases 20141209 1
The emergence of avian H7N9 viruses has raised concerns about its pandemic potential and prompted vaccine trials. At present, it is unknown whether there will be sufficient cross-reactive hemagglutinin (HA)-specific CD4 T-cell memory with seasonal influenza to facilitate antibody production to H7 HA. There has also been speculation that H7N9 will have few CD4 T-cell epitopes. In this study, we quantified the potential of seasonal influenza to provide memory CD4 T cells that can cross-reactively ...[more]