Ontology highlight
ABSTRACT:
SUBMITTER: Vorobyeva AG
PROVIDER: S-EPMC4482324 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PloS one 20150625 6
Bacterial nitroreductases (NTRs) have been widely utilized in the development of novel antibiotics, degradation of pollutants, and gene-directed enzyme prodrug therapy (GDEPT) of cancer that reached clinical trials. In case of GDEPT, since NTR is not naturally present in mammalian cells, the prodrug is activated selectively in NTR-transformed cancer cells, allowing high efficiency treatment of tumors. Currently, no bioluminescent probes exist for sensitive, non-invasive imaging of NTR expression ...[more]