New Metrics for Evaluating Viral Respiratory Pathogenesis.
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ABSTRACT:
SUBMITTER: Menachery VD
PROVIDER: S-EPMC4482571 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
New Metrics for Evaluating Viral Respiratory Pathogenesis.
Menachery Vineet D VD Gralinski Lisa E LE Baric Ralph S RS Ferris Martin T MT
PloS one 20150626 6
Viral pathogenesis studies in mice have relied on markers of severe systemic disease, rather than clinically relevant measures, to evaluate respiratory virus infection; thus confounding connections to human disease. Here, whole-body plethysmography was used to directly measure changes in pulmonary function during two respiratory viral infections. This methodology closely tracked with traditional pathogenesis metrics, distinguished both virus- and dose-specific responses, and identified long-term ...[more]
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