Ontology highlight
ABSTRACT:
SUBMITTER: Bhatt K
PROVIDER: S-EPMC4483585 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Journal of the American Society of Nephrology : JASN 20150113 7
Ischemia-reperfusion injury contributes to tissue damage and organ failure in clinical settings, but the underlying mechanism remains elusive and effective therapies are still lacking. Here, we identified microRNA 687 (miR-687) as a key regulator and therapeutic target in renal ischemia-reperfusion injury. We show that miR-687 is markedly upregulated in the kidney during renal ischemia-reperfusion in mice and in cultured kidney cells during hypoxia. MiR-687 induction under these conditions was m ...[more]