Dataset Information

Effect of variation of FGF2 genotypes on the risk of osteosarcoma susceptibly: a case control study.

ABSTRACT: OBJECTIVE:Genetic factors play an important role in osteosarcoma (OS) etiology and fibroblast growth factor 2 (FGF2) gene single polymorphisms may be involved. The aim of this study was to test whether FGF2 variants are associated with susceptibility to OS in a Chinese population. METHODS:A total of 151 subjects who were diagnosed as OS and 225 healthy age-matched controls were enrolled in the present study. Thers11737764 C/T SNP in FGF2 gene was genotyped in all the subjects. The SPSS software was used to investigate the association between the rs11737764 genotypes and OS susceptibility or severity. RESULTS:The genotype frequencies of the FGF2 rs11737764 C/T polymorphism were 44.4% (CC), 50.3% (CT) and 5.3% (TT) in OS patients, and 55.6% (CC), 43.1% (CT) and 1.3% (TT) in controls. Rs11737764 C/T was found to be significantly associated with increased risk and OS no matter what genetic model was used. CONCLUSION:In conclusion, our data demonstrated the FGF2 SNP rs11737764 was significantly associated with increased osteosarcoma susceptibility in Chinese Han Population.

SUBMITTER: Wang J

PROVIDER: S-EPMC4483889 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Effect of variation of FGF2 genotypes on the risk of osteosarcoma susceptibly: a case control study.

Wang Jiefeng J Liu Hongtao H Liu Xiaoyang X Qi Xiaojun X

International journal of clinical and experimental medicine 20150415 4

<h4>Objective</h4>Genetic factors play an important role in osteosarcoma (OS) etiology and fibroblast growth factor 2 (FGF2) gene single polymorphisms may be involved. The aim of this study was to test whether FGF2 variants are associated with susceptibility to OS in a Chinese population.<h4>Methods</h4>A total of 151 subjects who were diagnosed as OS and 225 healthy age-matched controls were enrolled in the present study. Thers11737764 C/T SNP in FGF2 gene was genotyped in all the subjects. The ...[more]

PMID: 26131213

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Project description:The objective of the study was to determine the genetic basis of Major Depressive Disorder, and the capacity to respond to antidepressant treatment. An association study of 21 candidate polymorphisms relevant to monoamine function and the mechanism of antidepressant response was conducted in 3 phenotypically distinct samples: a group with chronic or recurrent depression unable to respond to antidepressants (non-responders) (n = 58), a group capable of symptomatic improvement with or without treatment (responders) (n = 39), and volunteer controls (n = 85). The responders and non-responders constituted a larger group of depressed subjects.A candidate gene approach was employed to asses the genetics basis of Major Depressive Disorder. The genotypic frequencies of selected polymorphisms were compared between the controls and depressed subjects. To asses the genetics basis of the capacity to respond to antidepressant treatment, the responders were compared to the non-responders. Candidate genes were chosen based on functional studies and proximity to whole genome linkage findings in the literature. Risk genotypes were identified by previous functional studies and association studies.A statistically significant difference in genotype frequency for the SLC6A4 intron 2 VNTR was detected between the subjects with a history of depression and controls (p = 0.004). Surprisingly, a statistically significant difference was detected between responders and non-responders for the DRD4 exon III VNTR genotype frequencies (p = 0.009). Furthermore, a difference between the controls and depressed subjects as well as between the controls and non-responders was detected for the number and distribution of risk genotypes in each group.An association between several monoamine-related genes and Major Depressive Disorder is supported. The data suggest that the two depressive phenotypes are genetically different, inferring that the genetic basis for the capacity to respond to standard antidepressant treatment, and the genetic susceptibility to Major Depressive Disorder may be independent. In addition, a proof of concept is provided demonstrating that the number of risk genotypes may be an indication of susceptibility of major depressive disorder and the severity of the disorder.

Dataset Information

Effect of variation of FGF2 genotypes on the risk of osteosarcoma susceptibly: a case control study.

Publications

Effect of variation of FGF2 genotypes on the risk of osteosarcoma susceptibly: a case control study.

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