Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC4483916 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Li Jun J Wang Xiao-Ru XR Zhai Xiao-Wen XW Wang Hong-Sheng HS Qian Xiao-Wen XW Miao Hui H Zhu Xiao-Hua XH
International journal of clinical and experimental medicine 20150415 4
<h4>Objective</h4>The present study aims to investigate the correlation of polymorphisms of SLCO1B1 gene with the toxicity during therapy with the high-dose methotrexate (MTX) chemotherapy in childhood acute lymphoblastic leukemia.<h4>Methods</h4>We analyzed 2 polymorphisms (rs4149081 and rs11045897) in SLCO1B1 gene in 280 Chinese pediatric B-ALL patients, using MTX plasma concentration as an objective and quantifiable marker of toxicity. We utilized Enzyme-multiplied immunoassay technique (EMIT ...[more]