Ontology highlight
ABSTRACT:
SUBMITTER: Xin N
PROVIDER: S-EPMC6761274 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Xin Ning N Fen Zhou Z Li Cheng C Yan Xiao X Runming Jin J
Frontiers in pharmacology 20190919
An 11-year-old male patient with the deletion of <i>IKZF1</i> (Ikaros family zinc finger 1) and positive Breakpoint Cluster Region-C-Abelson oncogene 1(<i>BCR-ABL1</i>) acute lymphoblastic leukemia developed mucositis, gastrointestinal toxicity, hepatotoxicity, myelosuppression, and severe dermatologic toxicity during the first and second courses of high-dose methotrexate. The patient recovered completely after therapy. However, intracranial hemorrhage (ICH) occurred following oral methotrexate ...[more]