Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki S
PROVIDER: S-EPMC4486249 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Suzuki Shintaro S Urano Emiko E Hashimoto Chie C Tsutsumi Hiroshi H Nakahara Toru T Tanaka Tomohiro T Nakanishi Yuta Y Maddali Kasthuraiah K Han Yan Y Hamatake Makiko M Miyauchi Kosuke K Pommier Yves Y Beutler John A JA Sugiura Wataru W Fuji Hideyoshi H Hoshino Tyuji T Itotani Kyoko K Nomura Wataru W Narumi Tetsuo T Yamamoto Naoki N Komano Jun A JA Tamamura Hirokazu H
Journal of medicinal chemistry 20100701 14
Anti-HIV peptides with inhibitory activity against HIV-1 integrase (IN) have been found in overlapping peptide libraries derived from HIV-1 gene products. In a strand transfer assay using IN, inhibitory active peptides with certain sequential motifs related to Vpr- and Env-derived peptides were found. The addition of an octa-arginyl group to the inhibitory peptides caused a remarkable inhibition of the strand transfer and 3'-end-processing reactions catalyzed by IN and significant inhibition aga ...[more]