Ontology highlight
ABSTRACT:
SUBMITTER: Yin L
PROVIDER: S-EPMC4486258 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Yin Lichen L Chen Yongbing Y Zhang Zhonghai Z Yin Qian Q Zheng Nan N Cheng Jianjun J
Macromolecular rapid communications 20150123 5
A targeted micellar drug delivery system is developed from a biocompatible and biodegradable amphiphilic polyester, poly(Lac-OCA)-b-(poly(Tyr(alkynyl)-OCA)-g-mannose) (PLA-b-(PTA-g-mannose), that is synthesized via controlled ring-opening polymerization of O-carboxyanhydride (OCA) and highly efficient "Click" chemistry. Doxorubicin (DOX), a model lipophilic anticancer drug, can be effectively encapsulated into the micelles, and the mannose moiety allows active targeting of the micelles to cancer ...[more]