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Biodegradable micelles capable of mannose-mediated targeted drug delivery to cancer cells.

ABSTRACT: A targeted micellar drug delivery system is developed from a biocompatible and biodegradable amphiphilic polyester, poly(Lac-OCA)-b-(poly(Tyr(alkynyl)-OCA)-g-mannose) (PLA-b-(PTA-g-mannose), that is synthesized via controlled ring-opening polymerization of O-carboxyanhydride (OCA) and highly efficient "Click" chemistry. Doxorubicin (DOX), a model lipophilic anticancer drug, can be effectively encapsulated into the micelles, and the mannose moiety allows active targeting of the micelles to cancer cells that specifically express mannose receptors, which thereafter enhances the anticancer efficiency of the drug. Comprised entirely of biodegradable and biocompatible polyesters, this micellar system demonstrates promising potentials for targeted drug delivery and cancer therapy.

SUBMITTER: Yin L

PROVIDER: S-EPMC4486258 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Biodegradable micelles capable of mannose-mediated targeted drug delivery to cancer cells.

Yin Lichen L Chen Yongbing Y Zhang Zhonghai Z Yin Qian Q Zheng Nan N Cheng Jianjun J

Macromolecular rapid communications 20150123 5

A targeted micellar drug delivery system is developed from a biocompatible and biodegradable amphiphilic polyester, poly(Lac-OCA)-b-(poly(Tyr(alkynyl)-OCA)-g-mannose) (PLA-b-(PTA-g-mannose), that is synthesized via controlled ring-opening polymerization of O-carboxyanhydride (OCA) and highly efficient "Click" chemistry. Doxorubicin (DOX), a model lipophilic anticancer drug, can be effectively encapsulated into the micelles, and the mannose moiety allows active targeting of the micelles to cancer ...[more]

PMID: 25619623

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