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Mitochondria-targeted fluorescent polymersomes for drug delivery to cancer cells.

ABSTRACT: Mitochondria is an attractive target to deliver anticancer drugs. We have synthesized a cationic triphenylphosphonium ion conjugated fluorescent polymer which self-assembles into nanosized polymersomes and targets the encapsulated anticancer drug doxorubicin to cancer cell mitochondria.

SUBMITTER: Kulkarni PS 

PROVIDER: S-EPMC5098558 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Mitochondria-targeted fluorescent polymersomes for drug delivery to cancer cells.

Kulkarni P S PS   Haldar M K MK   Confeld M I MI   Langaas C J CJ   Yang X X   Qian S Y SY   Mallik S S  

Polymer chemistry 20160524 25

Mitochondria is an attractive target to deliver anticancer drugs. We have synthesized a cationic triphenylphosphonium ion conjugated fluorescent polymer which self-assembles into nanosized polymersomes and targets the encapsulated anticancer drug doxorubicin to cancer cell mitochondria. ...[more]

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