Ontology highlight
ABSTRACT:
SUBMITTER: Blevins MA
PROVIDER: S-EPMC4486263 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Blevins Melanie A MA Kouznetsova Jennifer J Krueger Aaron B AB King Rebecca R Griner Lesley Mathews LM Hu Xin X Southall Noel N Marugan Juan J JJ Zhang Qinghong Q Ferrer Marc M Zhao Rui R
Journal of biomolecular screening 20141204 5
Carboxyl-terminal binding protein (CtBP) is a transcriptional corepressor that suppresses multiple proapoptotic and epithelial genes. CtBP is overexpressed in many human cancers, and its overexpression increases stem cell-like features, epithelial-mesenchymal transition, and cancer cell survival. Knockdown of CtBP also increases apoptosis independent of p53 in cell culture. Therefore, targeting CtBP with small molecules that disrupt its interaction with transcription factor partners may be an ef ...[more]