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Iron(II)-Catalyzed Asymmetric Epoxidation of Trisubstituted ?,?-Unsaturated Esters.

ABSTRACT: An asymmetric epoxidation of trisubstituted ?,?-unsaturated esters is described. The oxidation utilizes a pseudo-C2-symmetric iron(II) catalyst [Fe(L*)2(CH3CN)(OTf)](OTf) and peracetic acid as oxidant, yielding the ?,?-epoxyesters in high enantiomeric purity (up to 99% ee).

SUBMITTER: Luo L

PROVIDER: S-EPMC4486291 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Iron(II)-Catalyzed Asymmetric Epoxidation of Trisubstituted α,β-Unsaturated Esters.

Luo Lan L Yamamoto Hisashi H

European journal of organic chemistry 20141201 35

An asymmetric epoxidation of trisubstituted α,β-unsaturated esters is described. The oxidation utilizes a pseudo-C2-symmetric iron(II) catalyst [Fe(L*)2(CH3CN)(OTf)](OTf) and peracetic acid as oxidant, yielding the α,β-epoxyesters in high enantiomeric purity (up to 99% ee). ...[more]

PMID: 26146482

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