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Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics.

ABSTRACT: We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via "Click" reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.

SUBMITTER: Cai K

PROVIDER: S-EPMC4486357 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics.

Cai Kaimin K Yen Jonathan J Yin Qian Q Liu Yang Y Song Ziyuan Z Lezmi Stéphane S Zhang Yanfeng Y Yang Xujuan X Helferich William G WG Cheng Jianjun J

Biomaterials science 20150701 7

We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via "Click" reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The ...[more]

PMID: 26146551

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