Ontology highlight
ABSTRACT:
SUBMITTER: Cai K
PROVIDER: S-EPMC4486357 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Biomaterials science 20150701 7
We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via "Click" reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The ...[more]