Intratumoral Heterogeneity of MAGE-C1/CT7 and MAGE-C2/CT10 Expression in Mucosal Melanoma.
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SUBMITTER: Curioni-Fontecedro A
PROVIDER: S-EPMC4486606 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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Intratumoral Heterogeneity of MAGE-C1/CT7 and MAGE-C2/CT10 Expression in Mucosal Melanoma.
Curioni-Fontecedro A A Pitocco R R Schoenewolf N L NL Holzmann D D Soldini D D Dummer R R Calvieri S S Moch H H Mihic-Probst D D Fitsche A A
BioMed research international 20150616
Mucosal melanoma is a rare disease, which differs from its cutaneous counterpart genetically and for its clinical behaviour. Moreover this is a heterogeneous disease based on the tissue of origin. As CT7 and CT10 are highly expressed in cutaneous melanoma and are immunogenic in this disease, we analysed their expression throughout the different subtypes of mucosal melanoma and tumor development. We detected a frequent expression of CT7 in primaries and corresponding metastases (55%) as well as f ...[more]
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