Ontology highlight
ABSTRACT:
SUBMITTER: Hussain MR
PROVIDER: S-EPMC4486731 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Hussain Muhammad Ramzan Manwar MR Baig Mukhtiar M Mohamoud Hussein Sheik Ali HS Ulhaq Zaheer Z Hoessli Daniel C DC Khogeer Ghaidaa Siraj GS Al-Sayed Ranem Radwan RR Al-Aama Jumana Yousuf JY
Saudi journal of biological sciences 20141023 4
The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies). The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade in human cancers and RAS/MAPK syndromes, and focuses the molecular basis and clinical genetics of BRAF to better understand its parallel involvement in both tumourigenesis and RAS/MAPK syndromes-Noonan ...[more]