Ontology highlight
ABSTRACT:
SUBMITTER: Domigan CK
PROVIDER: S-EPMC4487014 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Domigan Courtney K CK Warren Carmen M CM Antanesian Vaspour V Happel Katharina K Ziyad Safiyyah S Lee Sunyoung S Krall Abigail A Duan Lewei L Torres-Collado Antoni X AX Castellani Lawrence W LW Elashoff David D Christofk Heather R HR van der Bliek Alexander M AM Potente Michael M Iruela-Arispe M Luisa ML
Journal of cell science 20150508 12
Autocrine VEGF is necessary for endothelial survival, although the cellular mechanisms supporting this function are unknown. Here, we show that--even after full differentiation and maturation--continuous expression of VEGF by endothelial cells is needed to sustain vascular integrity and cellular viability. Depletion of VEGF from the endothelium results in mitochondria fragmentation and suppression of glucose metabolism, leading to increased autophagy that contributes to cell death. Gene-expressi ...[more]