Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling.
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ABSTRACT:
SUBMITTER: Sun S
PROVIDER: S-EPMC4828306 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
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Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling.
Sun Shaogang S Chen Song S Liu Fei F Wu Haige H McHugh Jonathan J Bergin Ingrid L IL Gupta Anita A Adams Denise D Guan Jun-Lin JL
Cancer cell 20151201 6
Angiosarcoma/lymphangiosarcoma is a rare malignancy with poor prognosis. We generated a mouse model with inducible endothelial-cell-specific deletion of Tsc1 to examine mTORC1 signaling in lymphangiosarcoma. Tsc1 loss increased retinal angiogenesis in neonates and led to endothelial proliferative lesions from vascular malformations to vascular tumors in adult mice. Sustained mTORC1 signaling was required for lymphangiosarcoma development and maintenance. Increased VEGF expression in tumor cells ...[more]
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