Ontology highlight
ABSTRACT:
SUBMITTER: Panagopoulos I
PROVIDER: S-EPMC4487666 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Panagopoulos Ioannis I Bjerkehagen Bodil B Gorunova Ludmila L Taksdal Ingeborg I Heim Sverre S
Oncology reports 20150605 2
We describe two cases of extraskeletal osteochondroma in which chromosome bands 12q14~15 were visibly rearranged through a pericentric inv(12). Molecular analysis of the first tumor showed that both transcript 1 (NM_003483) and transcript 2 (NM_003484) of HMGA2 were expressed. In the second tumor, the inv(12) detected by karyotyping had resulted in an HMGA2-SOX5 fusion transcript in which exons 1-3 of HMGA2 were fused with a sequence from intron 1 of SOX5. The observed pattern is similar to rear ...[more]