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Genetics of Type 2 Diabetes and Clinical Utility.

ABSTRACT: A large proportion of heritability of type 2 diabetes (T2D) has been attributed to inherent genetics. Recent genetic studies, especially genome-wide association studies (GWAS), have identified a multitude of variants associated with T2D. It is thus reasonable to question if these findings may be utilized in a clinical setting. Here we briefly review the identification of risk loci for T2D and discuss recent efforts and propose future work to utilize these loci in clinical setting-for the identification of individuals who are at particularly high risks of developing T2D and for the stratification of specific health-care approaches for those who would benefit most from such interventions.

SUBMITTER: Dorajoo R

PROVIDER: S-EPMC4488669 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Genetics of Type 2 Diabetes and Clinical Utility.

Dorajoo Rajkumar R Liu Jianjun J Boehm Bernhard O BO

Genes 20150623 2

A large proportion of heritability of type 2 diabetes (T2D) has been attributed to inherent genetics. Recent genetic studies, especially genome-wide association studies (GWAS), have identified a multitude of variants associated with T2D. It is thus reasonable to question if these findings may be utilized in a clinical setting. Here we briefly review the identification of risk loci for T2D and discuss recent efforts and propose future work to utilize these loci in clinical setting-for the identif ...[more]

PMID: 26110315

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