Genetics, pathogenesis and clinical interventions in type 1 diabetes.
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ABSTRACT:
SUBMITTER: Bluestone JA
PROVIDER: S-EPMC4959889 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Genetics, pathogenesis and clinical interventions in type 1 diabetes.
Bluestone Jeffrey A JA Herold Kevan K Eisenbarth George G
Nature 20100401 7293
Type 1 diabetes is an autoimmune disorder afflicting millions of people worldwide. Once diagnosed, patients require lifelong insulin treatment and can experience numerous disease-associated complications. The last decade has seen tremendous advances in elucidating the causes and treatment of the disease based on extensive research both in rodent models of spontaneous diabetes and in humans. Integrating these advances has led to the recognition that the balance between regulatory and effector T c ...[more]
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