Drusen and photoreceptor abnormalities in African-Americans with intermediate non-neovascular age-related macular degeneration.

ABSTRACT:

Purpose/aim

To investigate the relationship of drusen and photoreceptor abnormalities in African-American (AA) patients with intermediate non-neovascular age-related macular degeneration (AMD).

Materials and methods

AA patients with intermediate AMD (n = 11; age 52-77 years) were studied with spectral-domain optical coherence tomography. Macular location and characteristics of large drusen (≥125 µm) were determined. Thickness of photoreceptor laminae was quantified overlying drusen and in other macular regions. A patient with advanced AMD (age 87) was included to illustrate the disease spectrum.

Results

In this AA patient cohort, the spectrum of changes known to occur in AMD, including large drusen, sub-retinal drusenoid deposits and geographic atrophy, were identifie

SUBMITTER: Sadigh S 

PROVIDER: S-EPMC4489141 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature