Ontology highlight
ABSTRACT:
SUBMITTER: Malik L
PROVIDER: S-EPMC4489154 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Malik Laeeq L Mejia Alex A Parsons Helen H Ehler Benjamin B Mahalingam Devalingam D Brenner Andrew A Sarantopoulos John J Weitman Steven S
Cancer chemotherapy and pharmacology 20140923 5
<h4>Purpose</h4>Drug development in oncology is resource intensive and has a high failure rate. In this exploratory analysis, we aimed to identify the characteristics and outcomes of published Phase I studies associated with future Food and Drug Administration (FDA) approval.<h4>Methods</h4>Phase I studies of approved and non-approved anticancer agents between 2000 and 2013 were retrospectively examined. Fisher's exact and chi-squared tests were used to compare the potential predictive measures. ...[more]