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The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes.

ABSTRACT: Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and mortality rates, and soaring health-care costs. Developing interventions requires a comprehensive understanding of the mechanisms by which excess hepatic lipid develops and causes hepatic insulin resistance and type 2 diabetes. Proposed mechanisms implicate various lipid species, inflammatory signalling and other cellular modifications. Studies in mice and humans have elucidated a key role for hepatic diacylglycerol activation of protein kinase C? in triggering hepatic insulin resistance. Therapeutic approaches based on this mechanism could alleviate the related epidemics of non-alcoholic fatty liver disease and type 2 diabetes.

SUBMITTER: Perry RJ

PROVIDER: S-EPMC4489847 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes.

Perry Rachel J RJ Samuel Varman T VT Petersen Kitt F KF Shulman Gerald I GI

Nature 20140601 7503

Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and mortality rates, and soaring health-care costs. Developing interventions requires a comprehensive understanding of the mechanisms by which excess hepatic lipid develops and causes hepatic insulin resistance and type 2 diabetes. Proposed mechanisms implicate various lipid species, inflammatory signalling and other cellu ...[more]

PMID: 24899308

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