Ontology highlight
ABSTRACT:
SUBMITTER: Hu S
PROVIDER: S-EPMC4489885 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Hu Siqi S Li Jian J Xu Fengwen F Mei Shan S Le Duff Yann Y Yin Lijuan L Pang Xiaojing X Cen Shan S Jin Qi Q Liang Chen C Guo Fei F
PLoS genetics 20150702 7
The SAM domain and HD domain containing protein 1 (SAMHD1) inhibits retroviruses, DNA viruses and long interspersed element 1 (LINE-1). Given that in dividing cells, SAMHD1 loses its antiviral function yet still potently restricts LINE-1, we propose that, instead of blocking viral DNA synthesis by virtue of its dNTP triphosphohydrolase activity, SAMHD1 may exploit a different mechanism to control LINE-1. Here, we report a new activity of SAMHD1 in promoting cellular stress granule assembly, whic ...[more]