Ontology highlight
ABSTRACT:
SUBMITTER: Gilad D
PROVIDER: S-EPMC4490144 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Gilad David D Shorer Sharon S Ketzef Maya M Friedman Alon A Sekler Israel I Aizenman Elias E Hershfinkel Michal M
Neurobiology of disease 20150103
The aim of this study was to investigate the role of the synaptic metabotropic zinc receptor mZnR/GPR39 in physiological adaptation to epileptic seizures. We previously demonstrated that synaptic activation of mZnR/GPR39 enhances inhibitory drive in the hippocampus by upregulating neuronal K(+)/Cl(-) co-transporter 2 (KCC2) activity. Here, we first show that mZnR/GPR39 knockout (KO) adult mice have dramatically enhanced susceptibility to seizures triggered by a single intraperitoneal injection o ...[more]