Ontology highlight
ABSTRACT:
SUBMITTER: Longley RJ
PROVIDER: S-EPMC4490344 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Longley Rhea J RJ Salman Ahmed M AM Cottingham Matthew G MG Ewer Katie K Janse Chris J CJ Khan Shahid M SM Spencer Alexandra J AJ Hill Adrian V S AVS
Scientific reports 20150703
The development of an efficacious Plasmodium falciparum malaria vaccine remains a top priority for global health. Vaccination with irradiated sporozoites is able to provide complete sterile protection through the action of CD8(+) T cells at the liver-stage of infection. However, this method is currently unsuitable for large-scale deployment and focus has instead turned to the development of sub-unit vaccines. Sub-unit vaccine efforts have traditionally focused on two well-known pre-erythrocytic ...[more]