Ontology highlight
ABSTRACT:
SUBMITTER: Malito E
PROVIDER: S-EPMC4490488 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Malito Enrico E Carfi Andrea A Bottomley Matthew J MJ
International journal of molecular sciences 20150609 6
The use of protein X-ray crystallography for structure-based design of small-molecule drugs is well-documented and includes several notable success stories. However, it is less well-known that structural biology has emerged as a major tool for the design of novel vaccine antigens. Here, we review the important contributions that protein crystallography has made so far to vaccine research and development. We discuss several examples of the crystallographic characterization of vaccine antigen stru ...[more]