Dataset Information

The association between marine n-3 polyunsaturated fatty acid levels and survival after renal transplantation.

ABSTRACT:

Background and objectives

Several studies have reported beneficial cardiovascular effects of marine n-3 polyunsaturated fatty acids. To date, no large studies have investigated the potential benefits of marine n-3 polyunsaturated fatty acids in recipients of renal transplants.

Design, setting, participants, & measurements

In this observational cohort study of 1990 Norwegian recipients of renal transplants transplanted between 1999 and 2011, associations between marine n-3 polyunsaturated fatty acid levels and mortality were investigated by stratified analysis and multivariable Cox proportional hazard regression analysis adjusting for traditional and transplant-specific mortality risk factors. Marine n-3 polyunsaturated fatty acid levels in plasma phospholipids were measured by gas chromatography in a stable phase 10 weeks after transplantation.

Results

There were 406 deaths (20.4%) during a median follow-up period of 6.8 years. Mortality rates were lower in patients with high marine n-3 polyunsaturated fatty acid levels (≥7.95 weight percentage) compared with low levels (<7.95 weight percentage) for all age categories (pooled mortality rate ratio estimate, 0.69; 95% confidence interval, 0.57 to 0.85). When divided into quartiles according to marine n-3 polyunsaturated fatty acid levels, patients in the upper quartile compared with the lower quartile had a 56% lower risk of death (adjusted hazard ratio, 0.44; 95% confidence interval, 0.26 to 0.75) using multivariable Cox proportional hazard regression analysis. There was a lower hazard ratio for death from cardiovascular disease with high levels of marine n-3 polyunsaturated fatty acid and a lower hazard ratio for death from infectious disease with high levels of the marine n-3 polyunsaturated fatty acid eicosapentaenoic acid, whereas there was no association between total or individual marine n-3 polyunsaturated fatty acid levels and cancer mortality.

Conclusions

Higher plasma phospholipid marine n-3 polyunsaturated fatty acid levels were independently associated with better patient survival.

SUBMITTER: Eide IA

PROVIDER: S-EPMC4491303 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Publications

The association between marine n-3 polyunsaturated fatty acid levels and survival after renal transplantation.

Eide Ivar A IA Jenssen Trond T Hartmann Anders A Diep Lien M LM Dahle Dag O DO Reisæter Anna V AV Bjerve Kristian S KS Christensen Jeppe H JH Schmidt Erik B EB Svensson My M

Clinical journal of the American Society of Nephrology : CJASN 20150610 7

<h4>Background and objectives</h4>Several studies have reported beneficial cardiovascular effects of marine n-3 polyunsaturated fatty acids. To date, no large studies have investigated the potential benefits of marine n-3 polyunsaturated fatty acids in recipients of renal transplants.<h4>Design, setting, participants, & measurements</h4>In this observational cohort study of 1990 Norwegian recipients of renal transplants transplanted between 1999 and 2011, associations between marine n-3 polyunsa ...[more]

PMID: 26063768

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Dataset Information

The association between marine n-3 polyunsaturated fatty acid levels and survival after renal transplantation.

Background and objectives

Design, setting, participants, & measurements

Results

Conclusions

Publications

The association between marine n-3 polyunsaturated fatty acid levels and survival after renal transplantation.

Similar Datasets

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