Antitumor activity of a rhenium (I)-diselenoether complex in experimental models of human breast cancer.
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ABSTRACT:
SUBMITTER: Collery P
PROVIDER: S-EPMC4491361 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
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Antitumor activity of a rhenium (I)-diselenoether complex in experimental models of human breast cancer.
Collery Philippe P Mohsen Ahmed A Kermagoret Anthony A Corre Samantha S Bastian Gérard G Tomas Alain A Wei Ming M Santoni François F Guerra Nadia N Desmaële Didier D d'Angelo Jean J
Investigational new drugs 20150626 4
Rhenium (I)-diselenother (Re-diselenoether) is a water soluble metal-based compound, combining one atom of rhenium and two atoms of selenium. This compound has been reported to exhibit marked activities against several solid tumor cell lines. We now disclose an improved synthesis of this complex. The Re-diselenoether showed a potent inhibitory effect on MDA-MB231 cell division in vitro, which lasted when the complex was no longer present in the culture. Re-diselenoether induced a remarkable redu ...[more]
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