Ontology highlight
ABSTRACT:
SUBMITTER: Konkankit CC
PROVIDER: S-EPMC6512002 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Konkankit Chilaluck C CC King A Paden AP Knopf Kevin M KM Southard Teresa L TL Wilson Justin J JJ
ACS medicinal chemistry letters 20190423 5
The rhenium(I) complex <i>fac</i>-[Re(CO)<sub>3</sub>(2,9-dimethyl-1,10-phenanthroline)(OH<sub>2</sub>)]<sup>+</sup> (<b>1</b>) was previously shown to exhibit potent in vitro anticancer activity in a manner distinct from conventional platinum-based drugs (<i>J. Am. Chem. Soc.</i> <b>2017</b>, <i>139</i>, 14302-14314). In this study, we report further efforts to explore its aqueous speciation and antitumor activity. The cellular uptake of <b>1</b> was measured in A2780 and cisplatin-resistant A2 ...[more]